10th East-West Immunogenetics Conference (EWIC)

Wrocław 2016

April 21-23, 2016

April 21, 2016 (Thursday), Academy of Fine Arts

PLENARY SESSION I: Pharmacogenetics: Ron HN van Schaik, Andrei A Gilep
9:15 Pharmacogenetics: do you have your DNA passport? RHN van Schaik (Rotterdam; The Netherlands)
9:45 Endocrine disorders and psychiatry: drug discovery and pharmacogenomics. AA Gilep (Minsk; Belarus)
10:15 Pharmacogenetics in immunosuppressive management (transplantation and rheumatoid arthritis) M Droździk (Szczecin; Poland)
10:45 Genetic and molecular factors and their role in response to therapy in selected hematological malignancies. A Butrym (Wrocław; Poland)
10:55 High rate of in-stent restenosis (reoclusions) appearing shortly after endovascular treatment of peripheral arterial occlusive disease can result of reduced pharmacological platelet blockage associated with cytochrome P450 2C19*2 variant. I Wybrańska (Kraków; Poland)
11:05 Pharmacogenetic testing for statin-induced myopathy: method implementation and risk variant distribution in a Czech population. J Petřková (Olomouc; Czech Republic)
11:15 – 11:30COFFEE BREAK
PLENARY SESSION II: Organ Transplantation: Maria Boratyńska, Dariusz Patrzałek
11:30 Transplantology: challenges for today. D Patrzałek (Wrocław; Poland)
12:00 Antigen match, ischemia and death and transplant immunogenicity. M Kosieradzki (Warszawa; Poland)
12:30 Role of BAFF cytokine in kidney transplant rejection. A Slavcev (Prague; Czech Republic)
12:40 Impact of HLA allele polymorphisms in liver transplantation. B Palfi (Zagreb; Croatia)
12:50 Outcomes of Basiliximab and Thymoglobulin induction in recipients under 50 years old after heart transplantation. M Simonenko (St. Petersburg; Russia)
13:00 Allogeneic skin graft application in the treatment of burn wounds. M Misiuga (Siemianowice Śląskie; Poland)
13:10 – 14:00LUNCH and POSTER SESSION I: Martin Petrek, Jacek Nowak
PLENARY SESSION III: Disease Association: Elissaveta Naumova, Anna Wójcicka
14:00 Immunogenetics factors involved in cancer. E Naumova (Sofia; Bulgaria)
14:30 MicroRNAs in diagnostics and prognostics of human diseases. A Wójcicka (Warszawa; Poland)
15:00 ERAP2 variants influence the risk of Psoriatic Arthritis in HLA-B27-negative patients. OM Popa (Bucharest; Romania)
15:10 Comparison of associations of endoplasmic reticulum aminopeptidase 1 polymorphisms with non-small cell lung cancer in Poles and Chinese. P Kuśnierczyk (Wrocław; Poland)
15:20 HLA typing as a diagnostic tool for narcolepsy. M Vraná (Prague, Czech Republic)
15:30 – 15:45COFFEE BREAK
PLENARY SESSION IV: Next Generation Methods (I): Maciej Borowiec, Jacek Nowak
15:45 Genetic factors of diabetes - molecular diagnosis of selected cases. M Borowiec (Łódź; Poland)
16:05 Agilent strategy and portfolio for clinical applications. A Puppo (Agilent Technologies)
16:25 ICELL8TM, A Versatile Single Cell Analysis System to Process Thousands of Individual Cells. D Liber (WaferGen BioSystems)
16:40 FluoGene, the automated TaqMan based HLA Typing Technology with the speed of endpoint fluorescence detection. S Jacobs (Inno-train Diagnostik)
16:55 SSP typing in real time – Introducing QTYPE. A Steiner (Olerup)
17:10 SeqCap EZ MedExome Target Enrichment Kit. Coverage with Confidence. R Kochanowski (Roche)

April 22, 2016 (Friday), Academy of Fine Arts

PLENARY SESSION V: Hematological Diseases and Stem Cell Transplantation: Joannis Mytilineos, Przemysław Juszczyński
9:00 Single centre experience in bioethical problems in children stem cell transplantation. A Chybicka (Wrocław; Poland)
9:30 Compatibility criteria in unrelated stem cell transplantation - HLA and beyond. J Mytilineos (Ulm; Germany)
10:00 Prediction of NK cell licensing level in selection of hematopoietic stem cell donor. J Nowak (Warszawa; Poland)
10:10 Profile of inflammation-associated proteins in early post-transplant samples of patients after allogeneic haematopoietic stem cell transplantation. F Mrazek (Olomouc; Czech Republic)
10:20 The associations between BTLA gene polymorphisms and susceptibility to chronic lymphocytic leukaemia. L Karabon (Wrocław; Poland)
10:30 Expression of Toll like receptors in patients with chronic lymphocytic leukemia. J Rybka (Wrocław; Poland)
10:40 – 11:00COFFEE BREAK
PLENARY SESSION VI: Modern Approaches in Therapy: Andrzej Lange, Piotr Trzonkowski
11:00 Intra-bone route of donor lymphocyte infusion favors anti-leukemic allo-reactivity not increasing the risk of acute GvHD. A Lange (Wrocław; Poland)
11:30 Emerging strategies of targeting the crosstalk between tumor cell and the microenvironment in lymphoid malignancies. P Juszczyński (Warszawa; Poland)
12:00 Therapy with T regulatory cells – past, present and future. P Trzonkowski (Gdańsk; Poland)
12:30 Studies on the biological properties of olfactory ensheathing glial cells and their application in the treatment of spinal cord injuries. W Fortuna & R Międzybrodzki (Wrocław; Poland)
13:00 Isolation, production and transplantation of the amniotic stem cells culture according to Good Manufacturing Practice regulations. D Kitala (Siemianowice Śląskie; Poland)
13:10 – 14:00LUNCH and POSTER SESSION II: Renata Zunec, Monika Baj-Krzyworzeka
PLENARY SESSION VII: Population Genetics: Levon Yepiskoposyan, Piotr Kuśnierczyk
14:00 Genetic history of Armenians: answered and pending questions. L Yepiskoposyan (Yerevan; Armenia)
14:30 Whole exome sequencing for diagnosis of rare diseases - 3 year experience. R Płoski (Warszawa; Poland)
15:00 HIV-1 phylodynamics in Poland. M Parczewski (Szczecin; Poland)
15:30 Determination of HLA-A-B-DRB1 allele and haplotype frequencies in the Croatian population based on a family study. D Sviličić (Zagreb; Croatia)
15:40 New alleles in Russian population. M Loginova (Kirov; Russia)
15:50 CCR5DELTA32 allele frequencies in Russians, Bashkir and Tatar of Chelyabinsk region, Russia. I Govorovskaya (Chelyabinsk; Russia)
16:00 – 16:15COFFEE BREAK
PLENARY SESSION VIII: Next Generation Methods (II): Ingrid Fae, Gottfried Fischer
16:15 NXType™ - The Turnkey Solution for HLA Typing by NGS. C Lind (One Lambda, Thermo Fisher Scientific)
16:45 Full length HLA gene characterisation for submission of new and confirmatory alleles using a dual redundant sequencing strategy. V Albrecht (Dresden; Germany)
17:00 HLA NGS platforms, principles & strategies. J Duiker (GenDx)

April 23, 2016 (Saturday), Radisson Blu Hotel

PLENARY SESSION IX: EFI Business: Martin Petrek, Maciej Siedlar
9:00 How EFI can assist non-Western Europe and what these regions can give to EFI. M Petrek (Olomouc; Czech Republic)
9:15 The ESHI diploma - logistics and perspectives. T Slavcev (Prague; Czech Republic)
9:30 HLA typing for hematopoietic stem cell transplantation. B Vidan-Jeras (Ljubljana; Slovenia)
9:45 EFI- Standards version 6.3 in respect to NGS Technology: additional HLA typing resolution levels. I Fae (Vienna; Austria)
10:00 Results of the Last External Proficiency Testing Exercise for Central Europe Transplantation (CET). G Fischer (Vienna; Austria)
10:15 HLA Proficiency Testing for Central and East Europe – outcomes of the XXI trial. K Bogunia-Kubik (Wrocław; Poland)
10:30Best Presentation Awards: Katarzyna Bogunia-Kubik, Lidia Karabon
10:45 - 11:00COFFEE BREAK
MultiGenBank Workshop: Edyta Pawlak-Adamska, Piotr Łacina
11:00 How to use the MultiGenBank platform? E Pawlak-Adamska and P Łacina (Wrocław; Poland)
11:45 One-carbon metabolism in schizophrenia: lessons from genetic and epigenetic studies. B Misiak (Wrocław; Poland)
12:00 Studies on genetic predisposition to sporadic chronic lymphocytic leukaemia. M Jasek (Wrocław; Poland)
12:15 Association study of functional polymorphisms in interleukins and interleukin receptors genes: IL1A, IL1B, IL1RA, IL6, IL6R, IL10, IL10RA and TGFB1 in schizophrenia. P Kapelski (Poznań; Poland)
12:30 – 13:30 LUNCH
13:30 - 15:00General Assembly of the Polish Society for Immunogenetics

April 21, 2016 (Thursday) - POSTER SESSION I:

P1. Characterisation of CYP2C19 gene variants by MassArray and Point-of-Care techniques and its application for pharmacogenetics of antithrombotic therapy
Jana Petřková, Lenka Kocourková, Veronika Žižková, Zdeněk Nosek, Martin Petřek (Olomouc; Czech Republic)

P2. Impact of the NKG2D genetic variants on clinical response to anti-TNF therapy
Milena Iwaszko, Jerzy Świerkot, Katarzyna Kolossa, Sławomir Jeka, Piotr Wiland, Katarzyna Bogunia-Kubik (Wrocław, Bydgoszcz; Poland)

P3. Tissue Typing Center Zagreb - view from outside and inside Eurotransplant
Renata Žunec (Zagreb; Croatia)

P4. Solid Phase Assay Anti-HLA antibodies and their impact on pediatric kidney graft function in one -year perspective
Barbara Piątosa, Aneta Rękawek, Ewa Kostecka, Katarzyna Siewiera, Monika Gierła, Jacek Rubik, Ryszard Grenda (Warszawa; Poland)

P5. Occurrence of autoantibodies in highly immunized potential kidney recipients
Iwona Wojciechowska-Koszko, Barbara Krasnodębska-Szponder, Paulina Roszkowska, Barbara Dołęgowska (Szczecin, Poland)

P6. Analysis of anti-HLA class II antibodies in patients classified to kidney transplant including the antibodies against DP and DQ antigens
Paulina Roszkowska, Barbara Krasnodębska-Szponder, Iwona Wojciechowska-Koszko, Barbara Dołęgowska (Szczecin; Poland)

P7. The impact of hyperbaric oxygen therapy on prolongation of skin allograft survival among burn patients
Marcelina Misiuga, Marek Kawecki, Justyna Glik, Wojciech Łabuś, Mariusz Nowak (Siemianowice Śląskie, Bielsko-Biała, Zabrze; Poland)

P8. Distribution of genes HLA-A, B loci in Russian patients with ulcerative colitis living in Chelyabinsk region
Daria S. Stashkevich, Anastasia O. Skladchikova, Tatiana A. Suslova, Alexander G. Vasilenko, Svetlana V. Beliaeva, Alexandra L. Burmistrova (Chelyabinsk; Russia)

P9. Altered mRNA expression of TMEM39A in multiple sclerosis patients
Marta Wagner, Maciej Sobczyński, Małgorzata Bilińska, Anna Pokryszko–Dragan, Małgorzata Cyrul, Piotr Kuśnierczyk, Monika Jasek (Wrocław; Poland)

P10. Relationships between the miRNA-146a polymorphism and expression in patients with rheumatoid arthritis
Dagmara Piątek, Jerzy Świerkot, Milena Iwaszko, Marzena Ciechomska, Piotr Wiland, Katarzyna Bogunia-Kubik (Wrocław, Warszawa; Poland)

P11. Anti-HLA antibody in patients group with SLE
Urszula Siekiera (Katowice; Poland)

P12. Polymorphisms in co-stimulatory CD28/CTLA-4 pathway genes and the risk of prostate cancer
Krzystof Tupikowski, Anna Tomkiewicz, Edyta Pawlak-Adamska, Anna Partyka, Andrzej Wojciechowski, Anna Kołodziej, Janusz Dembowski, Irena Frydecka, Romuald Zdrojowy, Lidia Karabon (Wrocław; Poland)

P13. Gene-gene association in cervical squamous cell carcinoma (CSCC) Polish population – preliminary studies
Edyta Pawlak-Adamska, Magdalena Bartosińska, Lidia Karabon, Iwona Wlodarska-Polinska, Barbara Izmajłowicz, Oskar Nowak, Agnieszka Ignatowicz-Pacyna, Jan Kornafel, Marcin Stepień, Rafał Matkowski, Irena Frydecka (Wrocław, Wałbrzych, Poznań; Poland)

P14. Interleukin 1 beta gene variability impact on etiology of recurrent aphthous stomatitis – data from a genetic association analysis in a Polish cohort of patients
Zuzanna Ślebioda, Marta Rozmiarek, Ewa Krawiecka, Elżbieta Szponar, Anna Kowalska (Poznań; Poland)

April 22, 2016 (Friday) - POSTER SESSION II:

P1. Impact of Killer cell immunoglobulin like receptors (KIR) on Hematopoietic Stem Cell Transplantation
Sally Elfishawi, Ghada Mossallam, Alaa Elhaddad, Raafat Abd Elfatta, Azza Kamel (Cairo; Egypt)

P2. Methodology of cell chimaerism monitoring in patients after allogeneic haematopoietic stem cell transplantation
Monika Leontovycova, Pavla Hrabakova, Sylvie Nadvornikova, Kristyna Pegova, Renata Prerovska, Martina Stankova, Dagmar Brezinova, Hana Cechova (Prague; Czech Republic)

P3. Peripheral blood progenitor cells mobilization is associated with G-CSF pathway genes expression changes on mRNA and protein levels
Katarzyna Gębura, Aleksandra Butrym, Tomasz Wróbel, Kazimierz Kuliczkowski, Katarzyna Bogunia-Kubik (Wrocław; Poland)

P4. Selection of haploidentical donors for hematopoietic stem cell transplantation, revisions in guidelines of Polish National Health Fund for family donor selection
Jacek Nowak, Klaudia Nestorowicz, Sławomir Gwozdowicz, Urszula Szlendak, Joanna Dziopa, Agnieszka Malinowska, Daria Pawliczak, Aleksandra Drapała (Warszawa; Poland)

P5. Evaluation of the donor-recipient matching process for the hematopoietic stem cell transplantation, the efficacy, duration and donor and patient-related causes of failure
Klaudia Nestorowicz, Elzbieta Graczyk-Pol, Renata Mika-Witkowska, Agnieszka Witkowska, Marta Rogatko-Koros, Jacek Nowak (Warszawa; Poland)

P6. 2 Million Samples Typed by NGS – Establishing a Successful High-Throughput Workflow for Registry Typing
Irina Böhme, Kathrin Lang, Viviane Albrecht, Lisa Hedrich, Jürgen Sauter, Jan Hofmann, Julia Pingel, Vinzenz Lange, Alexander H. Schmidt (Dresden, Tübingen; Germany)

P7. TNF α A allele (rs1800629 polymorphism) as a part haplotype consisting of HLA B*08 and DRB1*03 associates with a lower risk of aGvHD in patients post hematopoietic stem cells transplantation
Emilia Jaskula, Katarzyna Koscinska, Jacek Nowak, Monika Mordak-Domagala, Janusz Lange, Slawomira Kyrcz-Krzemien, Miroslaw Markiewicz, Wieslaw Wiktor Jedrzejczak, Krzysztof Warzocha, Jerzy Kowalczyk, Jolanta Gozdzik, Andrzej Lange; Polish Donor‐Recipient Matching Group (Wrocław, Warszawa, Katowice, Gdańsk, Lublin, Kraków; Poland)

P8. Interleukine-10 gene polymorphism in patients with multiple myeloma
Anastasia Pavlova, Ludmila Bubnova, Stanislav Bessmeltsev, Irina Pavlova (St. Petersburg; Russia)

P9. New insights into HLA-G promoter genotyping
Andrzej Wiśniewski, Marta Wagner, Andrzej Malinowski, Jacek R. Wilczyński, Michał Radwan, Paweł Radwan, Piotr Kuśnierczyk, Izabela Nowak (Wrocław, Łódź, Rzgów; Poland)

P10. HLA gene and haplotype frequencies in Russians from Rostov-on-Don region and comparisons with other Eurasian populations
Elvira E. Kudinova, Olga S. Savchenko, Mikhail N. Vavilov, Tatiana A. Suslova (Rostov, Chelyabinsk; Russia)

P11. HLA DRB*04 allele frequencies in Russians and Tatar of Chelyabinsk Region, Russia
Elena Khromova, Ksenia Khramova, Irina Govorovskaya, Svetlana Beliaeva, Michail Vavilov, Tatiana Suslova (Chelyabinsk; Russia)

P12. MSC if an excess decrease the angiogenetic potential of mononuclear marrow derived cells employed for treatment of pts with critical limb ischemia
Agata Borowik, Janusz Lange, Dorota Dłubek, Andrzej Lange (Wroclaw; Poland)

P13. Amniotic stem cells share clusters of differentiation of fibroblasts and keratinocytes, influencing their wound healing ability
Diana Kitala, Marek Kawecki, Agnieszka Klama-Baryła, Wojciech Łabuś, Justyna Glik, Małgorzata Kraut, Mariusz Nowak (Siemianowice Śląskie, Bielsko-Biała, Zabrze; Poland)

P14. Heightened sensitivity of neutrophils in familial Mediterranean fever
Gayane Manukyan, Martin Petrek, Eva Kriegova, Tigran Davtyan, Rustam Aminov (Yerevan, Armenia; Olomouc, Czech Republic; Aberdeen, United Kingdom)